Effect of low levels of dysfunctional oxidized high-density lipoproteins on atrial fibrillation


This project holds significant importance in the realm of heart rhythm analysis due to its focus on understanding the association between dysfunctional, oxidized high-density lipoprotein and atrial fibrillation, a leading cause of hospitalizations and cardiovascular morbidity worldwide.



Currently, many hospitalizations are caused by cardiovascular diseases, which are the most common cause of morbidity and mortality in the world. One important risk factor for cardiovascular disease is low levels of high-density lipoprotein (HDL).

Based on the results of previous research by the scientific team at the Department of Internal Medicine, University Hospital Ruppin-Brandenburg/Havel, it was noted that dysfunctional, oxidized HDL (HDLox) displays a robust association with atrial fibrillation.


The aim of this project is to verify whether HDLox significantly correlates with atrial fibrillation, and predisposes to remission of atrial fibrillation after rhythm control therapeutic approaches (electrical cardioversion, pulmonary vein isolation).


This prospective study includes 100 patients with paroxysmal or persistent atrial fibrillation after rhythm control. The patient group undergoes a blood test and transthoracic echocardiography. In addition, patients undergo a 7-day Holter test, which will disclose episodes of atrial fibrillation that may manifest subclinically.


The study will expand knowledge of the effects of HDLox on atrial fibrillation and the predisposition to atrial fibrillation remission after therapeutic rhythm control procedures.


Coordinating Center: Univeritatesklinikum Brandenburg an der Havel, Germany

Principal investigator: Nikolaos Pagonas